Intracerebroventricular administration of the thyroid hormone analog TRIAC increases its brain content in the absence of MCT8
Abstract
Patients lacking the thyroid hormone (TH) transporter MCT8 present abnormal serum levels of TH: low thyroxine and high triiodothyronine. They also have severe neurodevelopmental defects resulting from cerebral hypothyroidism, most likely due to impaired TH transport across the brain barriers. The use of TH analogs, such as triiodothyroacetic acid (TRIAC), that can potentially access the brain in the absence of MCT8 and restore at least a subset...
Paper Details
Title
Intracerebroventricular administration of the thyroid hormone analog TRIAC increases its brain content in the absence of MCT8
Published Date
Dec 6, 2019
Journal
Volume
14
Issue
12
Pages
e0226017 - e0226017
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