A practical guide for analysis of histone post-translational modifications by mass spectrometry: Best practices and pitfalls
Abstract
Advances in mass spectrometry (MS) have revolutionized the ability to measure global changes in histone post-translational modifications (PTMs). The method routinely quantifies over 60 modification states in a single sample, far exceeding the capabilities of traditional western blotting. Thus, MS-based histone analysis has become an increasingly popular tool for understanding how genetic and environmental factors influence epigenetic states....
Paper Details
Title
A practical guide for analysis of histone post-translational modifications by mass spectrometry: Best practices and pitfalls
Published Date
Dec 1, 2020
Journal
Volume
184
Pages
53 - 60
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