Targeted selection of HIV-specific antibody mutations by engineering B cell maturation
Abstract
Engineering better bnAbs A highly effective HIV vaccine has been the goal of vaccinologists for nearly 35 years. A successful vaccine would need to induce broadly neutralizing antibodies (bnAbs) that are capable of neutralizing multiple HIV strains (see the Perspective by Agazio and Torres). Steichen et al. report a strategy in which the first vaccine shot can lead to immune responses that generate desired bnAbs. By combining knowledge of human...
Paper Details
Title
Targeted selection of HIV-specific antibody mutations by engineering B cell maturation
Published Date
Dec 6, 2019
Journal
Volume
366
Issue
6470
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