Detection of DNA methyltransferase activity using template-free DNA polymerization amplification based on aggregation-induced emission

Volume: 590, Pages: 113532 - 113532
Published: Feb 1, 2020
Abstract
A sensitive and selective fluorescence assay for DNA methyltransferase (MTase) activity detection was designed based on aggregation-induced emission (AIE) and target initiated template-free DNA polymerization. Quaternized tetraphenylethene salt was synthesized as the AIE probe, which binds to single-stranded DNA by electrostatic interaction. A hairpin probe was designed with a specific sequence for DNA MTase. In the presence of DNA MTase, the...
Paper Details
Title
Detection of DNA methyltransferase activity using template-free DNA polymerization amplification based on aggregation-induced emission
Published Date
Feb 1, 2020
Volume
590
Pages
113532 - 113532
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