Innate Immune Response to Cytoplasmic DNA: Mechanisms and Diseases
Abstract
DNA has been known to be a potent immune stimulus for more than half a century. However, the underlying molecular mechanisms of DNA-triggered immune response have remained elusive until recent years. Cyclic GMP-AMP synthase (cGAS) is a major cytoplasmic DNA sensor in various types of cells that detect either invaded foreign DNA or aberrantly located self-DNA. Upon sensing of DNA, cGAS catalyzes the formation of cyclic GMP-AMP (cGAMP), which in...
Paper Details
Title
Innate Immune Response to Cytoplasmic DNA: Mechanisms and Diseases
Published Date
Apr 26, 2020
Journal
Volume
38
Issue
1
Pages
79 - 98
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