Controlling cell-to-cell variability with synthetic gene circuits.
Abstract
Cell-to-cell variability originating, for example, from the intrinsic stochasticity of gene expression, presents challenges for designing synthetic gene circuits that perform robustly. Conversely, synthetic biology approaches are instrumental in uncovering mechanisms underlying variability in natural systems. With a focus on reducing noise in individual genes, the field has established a broad synthetic toolset. This includes noise control by...
Paper Details
Title
Controlling cell-to-cell variability with synthetic gene circuits.
Published Date
Dec 20, 2019
Volume
47
Issue
6
Pages
1795 - 1804
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