Serotonin Regulates Adult β-Cell Mass by Stimulating Perinatal β-Cell Proliferation
Abstract
A sufficient β-cell mass is crucial for preventing diabetes, and perinatal β-cell proliferation is important in determining the adult β-cell mass. However, it is not yet known how perinatal β-cell proliferation is regulated. Here, we report that serotonin regulates β-cell proliferation through serotonin receptor 2B (HTR2B) in an autocrine/paracrine manner during the perinatal period. In β-cell–specific Tph1 knockout (Tph1 βKO) mice, perinatal...
Paper Details
Title
Serotonin Regulates Adult β-Cell Mass by Stimulating Perinatal β-Cell Proliferation
Published Date
Dec 5, 2019
Journal
Volume
69
Issue
2
Pages
205 - 214
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