The Use of Non-insulin Agents in Gestational Diabetes: Clinical Considerations in Tailoring Therapy

To assess evidence to date for use of non-insulin agents in treatment of gestational diabetes mellitus. There has been increasing interest in the use of non-insulin agents, primarily metformin and glyburide (which both cross the placenta). Metformin has been associated with less maternal weight gain; however, recent studies have shown a trend toward increased weight in offspring exposed to metformin in utero. Glyburide has been associated with...