Phosphodiesterase-5 inhibitors: Shedding new light on the darkness of depression?
Abstract
Phosphodiesterase-5 inhibitors (PDE5Is) are used to treat erectile dysfunction (ED). Recently, the antidepressant-like effect of PDE5Is was demonstrated in animal models of depression. In clinical settings, PDE5Is were studied only for ED associated depression. Hence, there are no studies evaluating the effects of PDE5Is for the treatment of major depressive disorder (MDD) without ED. In this review article, we aimed to discuss the use of PDE5Is...
Paper Details
Title
Phosphodiesterase-5 inhibitors: Shedding new light on the darkness of depression?
Published Date
Mar 1, 2020
Volume
264
Pages
138 - 149
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