Fork pausing complex engages topoisomerases at the replisome
Abstract
Replication forks temporarily or terminally pause at hundreds of hard-to-replicate regions around the genome. A conserved pair of budding yeast replisome components Tof1–Csm3 (fission yeast Swi1–Swi3 and human TIMELESS–TIPIN) act as a “molecular brake” and promote fork slowdown at proteinaceous replication fork barriers (RFBs), while the accessory helicase Rrm3 assists the replisome in removing protein obstacles. Here we show that the Tof1–Csm3...
Paper Details
Title
Fork pausing complex engages topoisomerases at the replisome
Published Date
Dec 5, 2019
Journal
Volume
34
Issue
1-2
Pages
87 - 98
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