Carbamylation and glycation compete for collagen molecular aging in vivo
Abstract
Tissue aging is a complex phenomenon involving molecular aging of matrix proteins, which mainly results from their progressive alteration by nonenzymatic post-translational modifications (NEPTMs) such as glycation and carbamylation. These two reactions, which correspond to the binding of reactive metabolites ( i.e . reducing sugars and urea-derived cyanate, respectively) on amino groups of proteins, occur during aging and are amplified in...
Paper Details
Title
Carbamylation and glycation compete for collagen molecular aging in vivo
Published Date
Dec 4, 2019
Journal
Volume
9
Issue
1
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