Ketoconazole: compatibility with pharmaceutical excipients using DSC and TG techniques

Ketoconazole (KTZ) is an antifungal agent responsible for the inhibition of 14-α-demethylase sterol. The drug–excipient compatibility studies play an important role in pharmaceutical formulations development. Interactions between drug and excipients may affect the chemical nature, stability, bioavailability and consequently the therapeutic efficacy and safety profile. The main goal of this work was to evaluate the compatibility of KTZ with some...