NADPH oxidase 4 mediates the protective effects of physical activity against obesity-induced vascular dysfunction

Aims Physical activity is one of the most potent strategies to prevent endothelial dysfunction. Recent evidence suggests vaso-protective properties of hydrogen peroxide (H2O2) produced by main endothelial NADPH oxidase isoform 4 (Nox4) in the vasculature. Therefore, we hypothesized that Nox4 connects physical activity with vaso-protective effects. Methods and results Analysis of the endothelial function using Mulvany Myograph showed endothelial...