Embryonal precursors of Wilms tumor.
Abstract
Adult cancers often arise from premalignant clonal expansions. Whether the same is true of childhood tumors has been unclear. To investigate whether Wilms tumor (nephroblastoma; a childhood kidney cancer) develops from a premalignant background, we examined the phylogenetic relationship between tumors and corresponding normal tissues. In 14 of 23 cases studied (61%), we found premalignant clonal expansions in morphologically normal kidney...
Paper Details
Title
Embryonal precursors of Wilms tumor.
Published Date
Dec 6, 2019
Journal
Volume
366
Issue
6470
Pages
1247 - 1251
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Notes
History