Embryonal precursors of Wilms tumor.

Science56.90
Volume: 366, Issue: 6470, Pages: 1247 - 1251
Published: Dec 6, 2019
Abstract
Adult cancers often arise from premalignant clonal expansions. Whether the same is true of childhood tumors has been unclear. To investigate whether Wilms tumor (nephroblastoma; a childhood kidney cancer) develops from a premalignant background, we examined the phylogenetic relationship between tumors and corresponding normal tissues. In 14 of 23 cases studied (61%), we found premalignant clonal expansions in morphologically normal kidney...
Paper Details
Title
Embryonal precursors of Wilms tumor.
Published Date
Dec 6, 2019
Journal
Volume
366
Issue
6470
Pages
1247 - 1251
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