Original paper
Structural insights into human Arginase-1 pH dependence and its inhibition by the small molecule inhibitor CB-1158
Abstract
Arginase-1 is a manganese-dependent metalloenzyme that catalyzes the hydrolysis of L-arginine into L-ornithine and urea. Arginase-1 is abundantly expressed by tumor-infiltrating myeloid cells that promote tumor immunosuppression, which is relieved by inhibition of Arginase-1. We have characterized the potencies of the Arginase-1 reference inhibitors (2S)-2-amino-6-boronohexanoic acid (ABH) and Nω-hydroxy-nor-L-arginine (nor-NOHA), and studied...
Paper Details
Title
Structural insights into human Arginase-1 pH dependence and its inhibition by the small molecule inhibitor CB-1158
Published Date
Jan 1, 2020
Volume
4
Pages
100014 - 100014
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Notes
History