Modeling antimalarial and antihuman African trypanosomiasis compounds: a ligand- and structure-based approaches
Abstract
This study examines the interaction of 137 antimalarial and antihuman African trypanosomiasis compounds [bis(2-aminoimidazolines), bisguanidinediphenyls and polyamines] on three different in vitro assays (Trypanosoma brucei rhodesiense (T.b.r.), Plasmodium falciparum (P.f.) and cytotoxicity-L6 cells). ΔTm values, wherever available, were also examined for the considered ligands. Eight DNA–ligand complexes and one DNA structure without ligand...
Paper Details
Title
Modeling antimalarial and antihuman African trypanosomiasis compounds: a ligand- and structure-based approaches
Published Date
Nov 23, 2019
Journal
Volume
24
Issue
4
Pages
1107 - 1124
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Notes
History