Autoimmunity as a target for chimeric immune receptor therapy: A new vision to therapeutic potential
Abstract
Chimeric immune receptors (CIRs) are functionally pleiotropic because they are artificially expressed on diverse cell types, which gives specificity to their function to anergize, kill, or protect cognate target cells. CIRs consist of chimeric antigen receptors (CARs) and B-cell antibody receptor (BAR) or chimeric autoantibody receptors (CAARs). Approval of CAR-T cell therapy by the Food and Drug Administration (FDA) has encouraged investigators...
Paper Details
Title
Autoimmunity as a target for chimeric immune receptor therapy: A new vision to therapeutic potential
Published Date
May 1, 2020
Journal
Volume
41
Pages
100645 - 100645
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