Low coverage whole genome sequencing enables accurate assessment of common variants and calculation of genome-wide polygenic scores
Abstract
Background Inherited susceptibility to common, complex diseases may be caused by rare, pathogenic variants (“monogenic”) or by the cumulative effect of numerous common variants (“polygenic”). Comprehensive genome interpretation should enable assessment for both monogenic and polygenic components of inherited risk. The traditional approach requires two distinct genetic testing technologies—high coverage sequencing of known genes to detect...
Paper Details
Title
Low coverage whole genome sequencing enables accurate assessment of common variants and calculation of genome-wide polygenic scores
Published Date
Nov 26, 2019
Journal
Volume
11
Issue
1
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