Controlling thel‐asparaginase extraction and purification by the appropriate selection of polymer/salt‐based aqueous biphasic systems

Published: Dec 15, 2019
Abstract
BACKGROUND l-Asparaginase (ASNase) is an important biopharmaceutical for the treatment of acute lymphoblastic leukemia (ALL); however, with some restrictions due to its high manufacturing costs. Aqueous biphasic systems (ABS) have been suggested as more economical platforms for the separation/purification of proteins, but a full understanding of the mechanisms behind the ASNase partition is still a major challenge. Polymer/salt-based ABS with...
Paper Details
Title
Controlling thel‐asparaginase extraction and purification by the appropriate selection of polymer/salt‐based aqueous biphasic systems
Published Date
Dec 15, 2019
Journal
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