Insulin Signaling as a Key Moderator in Myotonic Dystrophy Type 1

Myotonic dystrophy type 1 (DM1) is an autosomal dominant genetic disease characterised by multi-system involvement. Affected organ system include skeletal muscle, heart, gastro-intestinal system and the brain. In this review, we evaluate the evidence for alterations in insulin signalling and their relation to clinical DM1 features. We start by summarising the molecular pathophysiology of DM1. Next, an overview of normal insulin signalling...