Development of a multivalent acetylcholinesterase inhibitor via dynamic combinatorial chemistry

Volume: 150, Pages: 1184 - 1191
Published: May 1, 2020
Abstract
In this study, we report the generation of a polymer based dynamic combinatorial library (DCL) using aldehyde-functionalized linear poly(glycidol) and hydrazide derivatives as initial building blocks. In combination with tetrameric acetylcholinesterase (AChE), a certain type of amplified acylhydrazone side chain is identified and further used for the synthesis of a multivalent AChE inhibitor. The cytotoxicity and inhibition properties of the...
Paper Details
Title
Development of a multivalent acetylcholinesterase inhibitor via dynamic combinatorial chemistry
Published Date
May 1, 2020
Volume
150
Pages
1184 - 1191
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