The role of desmin alterations in mechanical electrical feedback in heart failure

Mechanoelectric feedback (MEF) was related to malignant arrhythmias in heart failure (HF). Desmin is a cytoskeleton protein and could be involved in MEF as a mechanoelectrical transducer. In this study, we will discuss the role of desmin alterations in mechanical electrical feedback in heart failure and its mechanisms.We used both an in vivo rat model and an in vitro cardiomyocyte model to address this issue. For the in vivo experiments, we...