Original paper
Activity-by-contact model of enhancer–promoter regulation from thousands of CRISPR perturbations
Abstract
Enhancer elements in the human genome control how genes are expressed in specific cell types and harbor thousands of genetic variants that influence risk for common diseases1–4. Yet, we still do not know how enhancers regulate specific genes, and we lack general rules to predict enhancer–gene connections across cell types5,6. We developed an experimental approach, CRISPRi-FlowFISH, to perturb enhancers in the genome, and we applied it to test...
Paper Details
Title
Activity-by-contact model of enhancer–promoter regulation from thousands of CRISPR perturbations
Published Date
Nov 29, 2019
Journal
Volume
51
Issue
12
Pages
1664 - 1669
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Notes
History