Harmicines − harmine and cinnamic acid hybrids as novel antiplasmodial hits

Volume: 187, Pages: 111927 - 111927
Published: Feb 1, 2020
Abstract
Harmicines constitute novel hybrid compounds that combine two agents with reported antiplasmodial properties, namely β-carboline harmine and a cinnamic acid derivative (CAD). Cu(I) catalyzed azide-alkyne cycloaddition was employed for the preparation of three classes of hybrid molecules: N-harmicines 6a-i, O-harmicines 7a-i and N,O-bis-harmicines 8a-g,i. In vitro antiplasmodial activities of harmicines against the erythrocytic stage of...
Paper Details
Title
Harmicines − harmine and cinnamic acid hybrids as novel antiplasmodial hits
Published Date
Feb 1, 2020
Volume
187
Pages
111927 - 111927
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