Methods for constructing treatment episodes and impact on exposure-outcome associations

Purpose To assess the impact on exposure time and outcome misclassifications, and consequent impact on exposure-outcome associations from treatment episode construction. We investigated the dosage assumptions of 1 unit per day, and 1 DDD per day, versus actual prescribed dosage under different handling of gaps and overlaps of prescriptions. Methods Data on mirtazapine and citalopram exposure (years 2006–2014) from the Swedish Prescribed Drug...