Delineating Human B Cell Precursor Development With Genetically Identified PID Cases as a Model
Abstract
B-cell precursors (BCP) arise from hematopoietic stem cells in bone marrow (BM). Identification and characterization of the different BCP subsets has contributed to the understanding of normal B-cell development. BCP first rearrange their immunoglobulin (Ig) heavy chain (IGH) genes to form the pre-B-cell receptor (pre-BCR) complex together with surrogate light chains. Appropriate signalling via this pre-BCR complex is followed by rearrangement...
Paper Details
Title
Delineating Human B Cell Precursor Development With Genetically Identified PID Cases as a Model
Published Date
Nov 26, 2019
Journal
Volume
10
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