Managing the challenge of drug-induced liver injury: a roadmap for the development and deployment of preclinical predictive models.

Volume: 19, Issue: 2, Pages: 131 - 148
Published: Feb 1, 2020
Abstract
Drug-induced liver injury (DILI) is a patient-specific, temporal, multifactorial pathophysiological process that cannot yet be recapitulated in a single in vitro model. Current preclinical testing regimes for the detection of human DILI thus remain inadequate. A systematic and concerted research effort is required to address the deficiencies in current models and to present a defined approach towards the development of new or adapted model...
Paper Details
Title
Managing the challenge of drug-induced liver injury: a roadmap for the development and deployment of preclinical predictive models.
Published Date
Feb 1, 2020
Volume
19
Issue
2
Pages
131 - 148
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