Impaired ATM activation in B cells is associated with bone resorption in rheumatoid arthritis
Abstract
Patients with rheumatoid arthritis (RA) may display atypical CD21-/lo B cells in their blood, but the implication of this observation remains unclear. We report here that the group of patients with RA and elevated frequencies of CD21-/lo B cells shows decreased ataxia telangiectasia-mutated (ATM) expression and activation in B cells compared with other patients with RA and healthy donor controls. In agreement with ATM involvement in the...
Paper Details
Title
Impaired ATM activation in B cells is associated with bone resorption in rheumatoid arthritis
Published Date
Nov 20, 2019
Volume
11
Issue
519
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