Review paper
IL33 receptor activation is IL33 isoform and receptor genotype specific
Published: Sep 28, 2019
Abstract
Introduction: Interleukin 33 (IL33) and its receptor (IL1RL1/ST2) play important roles in asthma development. Multiple IL33 isoforms have been identified, while IL1RL1 contains coding region polymorphisms associated with asthma. Aim: To characterise the ability of IL33 isoforms to activate IL1RL1 signalling and determine the role of IL1RL1 TIR signalling domain haplotypes. Methods: A NFKB/AP1 promoter driven secretory...
Paper Details
Title
IL33 receptor activation is IL33 isoform and receptor genotype specific
Published Date
Sep 28, 2019
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