Highly sensitive MLH1 methylation analysis in blood identifies a cancer patient with low-level mosaic MLH1 epimutation

Volume: 11, Issue: 1
Published: Nov 28, 2019
Abstract
Constitutional MLH1 methylation (epimutation) is a rare cause of Lynch syndrome. Low-level methylation (≤ 10%) has occasionally been described. This study aimed to identify low-level constitutional MLH1 epimutations and determine its causal role in patients with MLH1 -hypermethylated colorectal cancer. Eighteen patients with MLH1- hypermethylated colorectal tumors in whom MLH1 methylation was previously undetected in blood by...
Paper Details
Title
Highly sensitive MLH1 methylation analysis in blood identifies a cancer patient with low-level mosaic MLH1 epimutation
Published Date
Nov 28, 2019
Volume
11
Issue
1
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