Multiple roles of DNA2 nuclease/helicase in DNA metabolism, genome stability and human diseases

Volume: 48, Issue: 1, Pages: 16 - 35
Published: Nov 22, 2019
Abstract
DNA2 nuclease/helicase is a structure-specific nuclease, 5′-to-3′ helicase, and DNA-dependent ATPase. It is involved in multiple DNA metabolic pathways, including Okazaki fragment maturation, replication of ‘difficult-to-replicate’ DNA regions, end resection, stalled replication fork processing, and mitochondrial genome maintenance. The participation of DNA2 in these different pathways is regulated by its interactions with distinct groups of DNA...
Paper Details
Title
Multiple roles of DNA2 nuclease/helicase in DNA metabolism, genome stability and human diseases
Published Date
Nov 22, 2019
Volume
48
Issue
1
Pages
16 - 35
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