Methylglyoxal Metabolism and Aging-Related Disease: Moving from Correlation toward Causation

Methylglyoxal (MG) is a side-product of mainly glycolysis that together with reactive oxygen species (ROS) leads to cellular dysregulation in age-related diseases and is a potential causal factor behind diabetes. The glyoxalase system is the most important system in the metabolism of MG, but evidence indicates that other enzymes also play an important role in regulating MG levels. Although involved in cellular dysregulation, mild MG stress also...