Catalytic antibody (catabody) platform for age-associated amyloid disease: From Heisenberg’s uncertainty principle to the verge of medical interventions

Volume: 185, Pages: 111188 - 111188
Published: Jan 1, 2020
Abstract
Quantum mechanics-based design of useful catalytic antibodies (catabodies) failed because of the uncertain structure of the dynamic catalyst-substrate complex. The Catabody Platform emerged from discovery of beneficial germline gene catabodies that hydrolyzed self-proteins by transient covalent pairing of the strong catabody nucleophile with a weak target protein electrophile. Catabodies have evolved by Darwinian natural selection for protection...
Paper Details
Title
Catalytic antibody (catabody) platform for age-associated amyloid disease: From Heisenberg’s uncertainty principle to the verge of medical interventions
Published Date
Jan 1, 2020
Volume
185
Pages
111188 - 111188
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