CRISPR Diagnosis and Therapeutics with Single Base Pair Precision

Volume: 26, Issue: 3, Pages: 337 - 350
Published: Mar 1, 2020
Abstract
CRISPR-based genome editing at specific genomic locations is prone to mistargeting other genomic loci with similar DNA sequences. Hence, allele-specific targeting with single base pair precision has become one of the most critical issues of developing CRISPR-based diagnostics and therapeutics for disorders such as genetic diseases and cancer. Understanding the structures of CRISPR proteins in complex with the guide RNAs and the target DNAs...
Paper Details
Title
CRISPR Diagnosis and Therapeutics with Single Base Pair Precision
Published Date
Mar 1, 2020
Volume
26
Issue
3
Pages
337 - 350
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