TLR-2 and MyD88-Dependent Activation of MAPK and STAT Proteins Regulates Proinflammatory Cytokine Response and Immunity to Experimental Trypanosoma congolense Infection

Although it is known that Trypanosoma congolense infection in mice is associated with increased production of proinflammatory cytokines by macrophages and monocytes, the intracellular signaling pathways leading to the production of these cytokines remain unknown. Here, we investigated the innate receptors and intracellular signaling pathways that are involved in T. congolense-induced proinflammatory cytokine production in macrophages. We show...