Emerging molecular biomarkers for predicting therapy response in psoriatic arthritis: A review of literature.

Published on Feb 1, 2020in Clinical Immunology3.548
· DOI :10.1016/J.CLIM.2019.108318
Juliëtte Pouw2
Estimated H-index: 2
(UU: Utrecht University),
Emmerik F. A. Leijten4
Estimated H-index: 4
(UU: Utrecht University)
+ 1 AuthorsMarianne Boes37
Estimated H-index: 37
(UU: Utrecht University)
Abstract Psoriatic arthritis (PsA) is a heterogeneous, chronic inflammatory musculoskeletal disorder that affects ~0.1% of the population. PsA may severely impact quality-of-life and constitutes a significant economic burden on our health care system. While early effective treatment is deemed essential to prevent irreversible joint damage and functional impairment, not all patients respond to the same disease modifying anti-rheumatic drugs (DMARDs). DMARD options for PsA are rapidly evolving, yet only 50–60% of patients show a satisfactory response to their first-line DMARD therapy. Hence, there is an urgent medical need to predict which patients benefit from a particular treatment. To this end, molecular biomarkers capable of predicting therapeutic response are currently being scrutinized in clinical studies, that together should build a framework for clinical guidelines that improve personalized targeted treatment. In this review new developments within the field of biomarker discovery for predicting therapeutic response to DMARDs in PsA are examined.
  • References (76)
  • Citations (0)
📖 Papers frequently viewed together
4 Citations
78% of Scinapse members use related papers. After signing in, all features are FREE.
Background Tremendous opportunities for health research have been unlocked by the recent expansion of big data and artificial intelligence. However, this is an emergent area where recommendations for optimal use and implementation are needed. The objective of these European League Against Rheumatism (EULAR) points to consider is to guide the collection, analysis and use of big data in rheumatic and musculoskeletal disorders (RMDs). Methods A multidisciplinary task force of 14 international exper...
15 CitationsSource
#1Ester Del Duca (ISMMS: Icahn School of Medicine at Mount Sinai)H-Index: 1
#2Ana B. Pavel (ISMMS: Icahn School of Medicine at Mount Sinai)H-Index: 12
Last. Emma Guttman-Yassky (Rockefeller University)H-Index: 49
view all 14 authors...
#1Ana-Maria Orbai (JHUSOM: Johns Hopkins University School of Medicine)H-Index: 12
1 CitationsSource
#1James G. Krueger (Rockefeller University)H-Index: 96
#2Keith A. Wharton (Novartis)H-Index: 1
Last. Wolfgang Hueber (Novartis)H-Index: 11
view all 20 authors...
Abstract Background Hyperactivity of the IL-23/IL-17-axis is central to plaque psoriasis pathogenesis. Secukinumab, a fully human monoclonal antibody that selectively inhibits IL-17A, is approved for treatment of psoriasis, psoriatic arthritis, and ankylosing spondylitis. Secukinumab improves the complete spectrum of psoriasis manifestations, with durable clinical responses beyond 5 years of treatment. In the “feed-forward” model of plaque chronicity, IL-17A has been hypothesized as the key driv...
1 CitationsSource
#1Neil McHughH-Index: 55
#2Áine Maguire (Edin.: University of Edinburgh)H-Index: 1
Last. Farhan Mughal (Edin.: University of Edinburgh)H-Index: 1
view all 9 authors...
Objective This analysis aimed to evaluate the economic burden of patients with psoriatic arthritis (PsA) on the UK healthcare system and estimate the relationship between functional status and direct healthcare costs. Methods Functional status (measured using the Health Assessment Questionnaire– Disability Index [HAQ-DI]), demographics, disease history and healthcare resource use data were extracted from a cohort of patients at the Royal National Hospital for Rheumatic Diseases, Bath, UK. Each r...
1 CitationsSource
#1Jinwu Chen (Sichuan University)H-Index: 2
#2Xiaojie Li (Sichuan University)H-Index: 1
Last. Xu Song (Sichuan University)H-Index: 1
view all 15 authors...
Infections caused by drug-resistant “superbugs” pose an urgent public health threat due to the lack of effective drugs; however, certain mammalian proteins with intrinsic antibacterial activity might be underappreciated. Here, we reveal an antibacterial property against Gram-negative bacteria for factors VII, IX and X, three proteins with well-established roles in initiation of the coagulation cascade. These factors exert antibacterial function via their light chains (LCs). Unlike many antibacte...
2 CitationsSource
#1Bram Duyx (UM: Maastricht University)H-Index: 3
#2Gerard M. H. Swaen (UM: Maastricht University)H-Index: 35
Last. Maurice P. Zeegers (UM: Maastricht University)H-Index: 50
view all 5 authors...
Background Research articles tend to focus on positive findings in their abstract, especially if multiple outcomes have been studied. At the same time, search queries in databases are generally limited to the abstract, title and keywords fields of an article. Negative findings are therefore less likely to be detected by systematic searches and to appear in systematic reviews. We aim to assess the occurrence of this ‘abstract reporting bias’ and quantify its impact in the literature on the associ...
1 CitationsSource
#1Rossana ScrivoH-Index: 23
#2A GiardinoH-Index: 1
Last. Florenzo IannoneH-Index: 32
view all 13 authors...
OBJECTIVES: Recently, research has been focused on the identification of predictors of response to treatment in patients with active psoriatic arthritis (PsA). The objective of this study was to develop a model to predict the clinical response at 6 months in patients with PsA starting the anti-tumour necrosis factor-alpha golimumab. METHODS: This prospective observational study explored a range of factors, including demographic data and baseline characteristics of the disease, measures of diseas...
1 Citations
#1Urban Hellman (Umeå University)H-Index: 13
#2Anna Engström-Laurent (Umeå University)H-Index: 12
Last. Ulla Lindqvist (Uppsala University)H-Index: 14
view all 4 authors...
Objective: Low molecular mass hyaluronan causes inflammatory processes and can act as a pro-inflammatory cytokine in skin and other sites of activity in psoriatic arthritis (PsA). This study invest...
#1Kevin L. Winthrop (OHSU: Oregon Health & Science University)H-Index: 47
#2Michael E. Weinblatt (Brigham and Women's Hospital)H-Index: 78
Last. Daniel E. FurstH-Index: 101
view all 19 authors...
To develop a comprehensive listing of the greatest unmet scientific and clinical needs in rheumatology. The 20th annual international Targeted Therapies meeting brought more than 100 leading basic scientists and clinical researchers in rheumatology, immunology, epidemiology, molecular biology and other specialties. During the meeting, breakout sessions were convened, consisting of five disease-specific groups with 20–30 experts assigned to each group based on expertise. Specific groups included ...
2 CitationsSource
Cited By0