Systematic evaluation of the efficacy-effectiveness gap of systemic treatments in extensive disease small cell lung cancer (ED SCLC)

Background: The aim of this study is to assess the difference between outcomes in clinical trials and in real-world (efficacy-effectiveness gap) of systemic treatments for ED SCLC. Methods: All patients diagnosed with ED SCLC between 2008 and 2014 in four Dutch large teaching hospitals (Santeon network) were studied. For every patient, an efficacy-effectiveness factor (EE-factor) was calculated by dividing individual patients’...