MSH6 immunohistochemical heterogeneity in colorectal cancer: comparative sequencing from different tumor areas
Abstract
Mismatch repair protein (MMR) immunohistochemistry is an important tool in screening for Lynch syndrome in colorectal cancer patients. Unusual staining patterns such as heterogeneous MSH6 staining have been reported in colorectal and endometrial cancers. We aim to better understand MSH6 staining heterogeneity in colorectal cancer by comparative sequencing of different tumor areas for MMR and DNA polymerase mutations. Whole-section slides of 1754...
Paper Details
Title
MSH6 immunohistochemical heterogeneity in colorectal cancer: comparative sequencing from different tumor areas
Published Date
Feb 1, 2020
Journal
Volume
96
Pages
104 - 111
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