Astrocytic AEG‐1 regulates expression of TREK‐1 under acute hypoxia

TREK‐1 (TWIK‐related K+ channel), a member of the two‐pore domain K+ (K2P) channel family, is highly expressed in astrocytes, where it plays a key role in glutamate release and passive conductance. In addition, TREK‐1 is induced to protect neurons under pathological conditions such as hypoxia. However, the upstream regulation of TREK‐1 remains poorly understood. In this study, we found that AEG‐1 (astrocyte elevated gene‐1) regulates the...