Sequential activation of STIM1 links Ca 2+ with luminal domain unfolding
Abstract
The stromal interaction molecule 1 (STIM1) has two important functions, Ca2+ sensing within the endoplasmic reticulum and activation of the store-operated Ca2+ channel Orai1, enabling plasma-membrane Ca2+ influx. We combined molecular dynamics (MD) simulations with live-cell recordings and determined the sequential Ca2+-dependent conformations of the luminal STIM1 domain upon activation. Furthermore, we identified the residues within the...
Paper Details
Title
Sequential activation of STIM1 links Ca 2+ with luminal domain unfolding
Published Date
Nov 19, 2019
Journal
Volume
12
Issue
608
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