Parsing multiomics landscape of activated synovial fibroblasts highlights drug targets linked to genetic risk of rheumatoid arthritis

Pages: 861781
Published: Mar 23, 2020
Abstract
In rheumatoid arthritis (RA), synovial fibroblasts (SFs) produce a variety of pathogenic molecules in the inflamed synovium. Despite their potential importance, comprehensive genetic network of SFs under inflammatory conditions remains elusive. Here, to elucidate the actions of SFs and their contributions to RA pathogenesis, SFs, stimulated with 8 proinflammatory cytokines, were analyzed using genomic, epigenomic and transcriptomic approaches....
Paper Details
Title
Parsing multiomics landscape of activated synovial fibroblasts highlights drug targets linked to genetic risk of rheumatoid arthritis
Published Date
Mar 23, 2020
Journal
Pages
861781
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