Crystal structure of dopamine receptor D4 bound to the subtype selective ligand, L745870
Abstract
Multiple subtypes of dopamine receptors within the GPCR superfamily regulate neurological processes through various downstream signaling pathways. A crucial question about the dopamine receptor family is what structural features determine the subtype-selectivity of potential drugs. Here, we report the 3.5-angstrom crystal structure of mouse dopamine receptor D4 (DRD4) complexed with a subtype-selective antagonist, L745870. Our structure reveals...
Paper Details
Title
Crystal structure of dopamine receptor D4 bound to the subtype selective ligand, L745870
Published Date
Nov 21, 2019
Journal
Volume
8
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