Carbonic anhydrase inhibition and chemoreflex control of breathing: A litmus test for methazolamide as a viable alternative to acetazolamide

Carbonic anhydrase inhibitors are used in clinical, experimental and environmental settings to regulate acid–base balance in the blood and tissues. Acetazolamide is a carbonic anhydrase inhibitor routinely prescribed in the treatment of pulmonary disorders, glaucoma and sleep-disordered breathing. It is also commonly used prophylactically and therapeutically in acute mountain sickness. In the context of high altitude, acetazolamide is used to...