Recurrent hepatocellular carcinoma: Different strategies, same endpoint

Hepatic resection is recommended for patients with early stage hepatocellular carcinoma (HCC) in the setting of adequate liver function and future liver remnant. However, recurrence after resection remains a significant issue, with 5-year recurrence rates upward of 60% with variations in timing of recurrence and underlying tumor biology. The mechanisms resulting in recurrent HCC may be categorized into intrahepatic metastasis versus multicentric...