Alpha-mangostin decreased cellular senescence in human umbilical vein endothelial cells

The hyperglycemic condition in diabetes induces cellular senescence in vascular endothelial cells and causes cardiovascular complications. Alpha-mangostin is a xanthone found in Garcinia mangostana, and has shown protective effects in metabolic syndrome. In this study, the anti-senescence effects of alpha-mangostin in the hyperglycemic condition are investigated. HUVECs were incubated with high glucose for 6 days and co-treated by metformin or...