Increasing doses of ketamine curtail antidepressant responses and suppress associated synaptic signaling pathways

Volume: 380, Pages: 112378 - 112378
Published: Feb 1, 2020
Abstract
Clinical findings show that a single subanesthetic dose of ketamine elicits rapid antidepressant effects. Accumulating data suggests that ketamine blocks the N-methyl-D-aspartate receptor and results in specific effects on intracellular signaling including increased brain-derived neurotrophic factor (BDNF) protein expression, which augments synaptic responses required for rapid antidepressant effects. To further investigate this potential...
Paper Details
Title
Increasing doses of ketamine curtail antidepressant responses and suppress associated synaptic signaling pathways
Published Date
Feb 1, 2020
Volume
380
Pages
112378 - 112378
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