Dexmedetomidine prevents desflurane‐induced motor neuron death through NF‐KappaB pathway

Desflurane is one of the commonly used general anaesthetics. Recently, it was reported that desflurane caused neurotoxicity, raising concerns in clinical use. In this study, we found desflurane could affect viability and maturation in motor neurons. Dexmedetomidine, a α2‐adrenergic receptor agonist, could attenuate the effect of desflurane on motor neurons. This process was mediated by NF‐KappaB signalling. Interestingly, we also found that...