Short Disease Duration Is Associated With Increased Risk of Treatment Failure in Biologic-Treated Patients With Ulcerative Colitis

Background Longer disease duration is associated with inferior response to biologic therapy in Crohn’s disease. However, the effect of disease duration on response to biologic therapy in ulcerative colitis (UC) has not been well studied. Methods In a single-center retrospective cohort study of outpatients with UC starting a biologic agent, we evaluated treatment response by disease duration. The primary outcome was treatment failure (composite...