Histone chaperone FACT and curaxins: effects on genome structure and function

Volume: 2019
Published: Nov 29, 2019
Abstract
The histone chaperone FACT plays important roles in essentially every chromatin-associated process and is an important indirect target of the curaxin class of anti-cancer drugs. Curaxins are aromatiс compounds that intercalate into DNA and can trap FACT in bulk chromatin, thus interfering with its distribution and its functions in cancer cells. Recent studies have provided mechanistic insight into how FACT and curaxins cooperate to promote...
Paper Details
Title
Histone chaperone FACT and curaxins: effects on genome structure and function
Published Date
Nov 29, 2019
Volume
2019
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