Insulin sensitizes mechanosensitive ion channels, which aggravates pain

In addition to improving glycaemic control, insulin can aggravate neuropathic pain in diabetic patients post-treatment initiation. This pain is generally difficult to suppress by analgesics and responds only to removal of insulin treatment. The condition initially termed ‘insulin neuritis’ is now referred to as ‘treatment-induced diabetic neuropathy’ (TIDN) (Hwang & Davies, 2016). TIDN is largely believed to be due to neuronal damage in diabetic...